HIV-1 immunogens and strategies to drive antibody responses towards neutralization breadth
Abstract Despite enormous efforts no HIV-1 vaccine has been developed that elicits broadly neutralizing antibodies g35 coupe fender (bNAbs) to protect against infection to date.The high antigenic diversity and dense N-linked glycan armor, which covers nearly the entire HIV-1 envelope protein (Env), are major roadblocks for the development of bNAbs