HIV-1 immunogens and strategies to drive antibody responses towards neutralization breadth

HIV-1 immunogens and strategies to drive antibody responses towards neutralization breadth

Blog Article

Abstract Despite enormous efforts no HIV-1 vaccine has been developed that elicits broadly neutralizing antibodies g35 coupe fender (bNAbs) to protect against infection to date.The high antigenic diversity and dense N-linked glycan armor, which covers nearly the entire HIV-1 envelope protein (Env), are major roadblocks for the development of bNAbs by vaccination.In addition, the naive human antibody repertoire features a low frequency of exceptionally long heavy chain complementary determining regions (CDRH3s), which is a typical characteristic that many HIV-1 bNAbs use to penetrate the glycan armor.

Native-like Env trimer immunogens can induce potent but strain-specific neutralizing antibody responses in animal models but how to overcome the many obstacles towards the development of bNAbs remains a challenge.Here, we review recent HIV-1 Env immunization studies and discuss strategies to read more guide strain-specific antibody responses towards neutralization breadth.